Δ 9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner.

Javier OrihuelRoberto CapellánDavid Roura-MartínezMarcos UchaEmilio AmbrosioAlejandro Higuera-Matas

Published in: The international journal of neuropsychopharmacology (2022)

Adolescent THC affects specific aspects of reward- (and cocaine-) guided behavior and the function of a key brain region mediating these effects, in a remarkable sex-specific manner.

Keyphrases

prefrontal cortex
young adults
mental health
gene expression
white matter
genome wide
rna seq
resting state
dna methylation
brain injury