Pedigree investigation, clinical characteristics, and prognosis analysis of haematological disease patients with germline TET2 mutation.
Xia WuJili DengNanchen ZhangXiaoyan LiuXue ZhengTianyou YanWu YeYuping GongPublished in: BMC cancer (2022)
Germline TET2 mutation might have a family aggregation, and TET2 may be a predisposition gene for haematological malignancy under the other gene mutations as the second hit. Germline TET2 mutation may play a role in the proportion of blood and bone marrow cells and, most importantly, may be an adverse factor for MDS patients.
Keyphrases
- bone marrow
- dna repair
- end stage renal disease
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- mesenchymal stem cells
- peritoneal dialysis
- cell cycle arrest
- genome wide
- gene expression
- dna damage
- patient reported outcomes
- copy number
- oxidative stress
- dna methylation
- cell proliferation
- endoplasmic reticulum stress
- pi k akt