Oral Nanoparticles of SNX10-shRNA Plasmids Ameliorate Mouse Colitis.

Wei-Lian BaoQi-Biao WuBin HuDongdong SunShengnan ZhaoXiaoyan ShenHaibo ChengWeixing Shen

Published in: International journal of nanomedicine (2021)

Oral nanoparticles of SNX10-shRNA plasmid displayed dominant efficiency of SNX10 RNA interference in the colon and ameliorate mouse colitis via TLR signaling pathway. SNX10 is a new target for IBD treatment and nanoparticles of SNX10-shRNA plasmid might be a promising treatment option for IBD.

Keyphrases

escherichia coli
signaling pathway
crispr cas
immune response
toll like receptor
inflammatory response
epithelial mesenchymal transition
oxidative stress
pi k akt
induced apoptosis
replacement therapy