PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.

Olivia CyprisMonika EipelJulia FranzenCorinna RösselerVithurithra TharmapalanChao-Chung KuoMargherita VieriMiloš NikolićMartin KirschnerTim H BrümmendorfMartin ZenkeAngelika LampertFabian BeierWolfgang Wagner

Published in: Clinical epigenetics (2020)

Taken together, our results demonstrate that epigenetic aging is accelerated in DKC and AA, independent from telomere attrition. Furthermore, aberrant DNA methylation in PRDM8 provides another biomarker for bone marrow failure syndromes and modulation of this gene in cellular subsets may be related to the hematopoietic and neuronal phenotypes observed in premature aging syndromes.

Keyphrases

dna methylation
bone marrow
genome wide
gene expression
copy number
mesenchymal stem cells