In vitro Anticancer Effects of Vernonia amygdalina Leaf Extract and Green-Synthesised Silver Nanoparticles.

Julia JosephKang Zi KhorEmmanuel Jairaj MosesVuanghao LimMohd Yusmaidie AzizNozlena Abdul Samad

Published in: International journal of nanomedicine (2021)

VA ethanol extracts and VA silver nanoparticles decreased the cell viability in MCF-7 cells in a time and dose-dependent manner by inducing apoptosis and causing DNA damage. Further research is needed to elucidate the mechanism of action of VA leaf extracts and VA silver nanoparticles. This study is the first to report on the anticancer activity of VA silver nanoparticles in MCF-7 cells.

Keyphrases

silver nanoparticles
cell cycle arrest
induced apoptosis
dna damage
oxidative stress
endoplasmic reticulum stress
cell death
breast cancer cells
pi k akt
signaling pathway