Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis.
Charles W ButrickSydney ThaiKristy IglayEkene EnemchukwuSilvia TeeSusann VaranoCynthia GirmanLarry RadicanPaul N MuddCharles PoolePublished in: Neurourology and urodynamics (2020)
Anticholinergic use for ≥3 months increased the risk of dementia on average by an estimated 46% versus nonuse. This relationship was consistent in studies assessing overactive bladder medications. The risk of developing dementia should be carefully considered in the context of potential benefit before prescribing anticholinergics.