Activation of HIF-1α-mediated DNA methylation enzymes (DNMT3a and TET2) under hypoxic conditions regulates S100A6 transcription to promote lung cancer cell growth and metastasis.
Tengfei WangGenbao ZhuBo WangMengxue HuChen GongKemeng TanLa JiangXiaohong ZhuYuliu GengLili LiPublished in: Antioxidants & redox signaling (2024)
In lung cancer progression, hypoxia-induced factor HIF-1α combined with DNA methylation modifications co-regulates S100A6 transcriptional activation and promotes lung cancer cell growth and metastasis.