The effects of pre-emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C-reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial.
Ersin KahramanBanu CevikKemal Tolga SaracoğluPublished in: International journal of clinical practice (2021)
The pre-emptive administration of ibuprofen provided effective pain control after gynecologic laparoscopy. However, ibuprofen changed the thiol/disulfide homeostasis in favor of oxidation and had no beneficial effect in surgically induced oxidative stress.
Keyphrases
- clinical trial
- oxidative stress
- postoperative pain
- hydrogen peroxide
- open label
- double blind
- robot assisted
- chronic pain
- study protocol
- endometrial cancer
- phase ii
- pain management
- neuropathic pain
- ischemia reperfusion injury
- high dose
- diabetic rats
- nitric oxide
- induced apoptosis
- spinal cord injury
- phase iii
- low dose
- heat shock
- electron transfer
- heat shock protein