B cell phenotype and serum levels of interferons, BAFF, and APRIL in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C).

Adam KlocperkMarketa BloomfieldZuzana ParackovaLudovic AillotJiri FremuthLumir SasekJan DavidFilip FenclAneta SkotnicovaKaterina RejlovaMartin MagnerOndrej HrusakAnna Sediva

Published in: Molecular and cellular pediatrics (2023)

Our work shows the involvement of humoral immunity in MIS-C and hints at parallels with the pathophysiology of SLE, with autoreactive B cells driven towards autoantibody production by elevated BAFF.

Keyphrases

coronavirus disease
systemic lupus erythematosus
sars cov
immune response
young adults
oxidative stress
disease activity
case report