Cholinergic basal forebrain system degeneration underlies postural instability/gait difficulty and attention impairment in Parkinson's disease.
Chenqing WuHaoting WuCheng ZhouXiao-Jun GuanTao GuoZhengye CaoJingjing WuXiaocao LiuJingwen ChenJiaqi WenJianmei QinSijia TanXiaojie DuanmuWeijin YuanQianshi ZhengBaorong ZhangPeiyu HuangXiao-Jun XuMin-Ming ZhangPublished in: European journal of neurology (2023)
Our findings suggest that degeneration of the cBF system in PD, from the cBF to its fiber tract and cortical projection, plays an important role in cognitive-motor interaction.