In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38.

Joshua PaceJane J LeeMadduri SrinivasaraoShivakrishna KallepuPhilip S LowMark Niedre

Published in: Molecular imaging and biology (2024)

This work shows the feasibility of labeling CTCs in vivo with OTL38 and detection with DiFC. Although further refinement of the DiFC instrument and signal processing algorithms and testing with other animal models is needed, this work may eventually pave the way for human use of DiFC.

Keyphrases

circulating tumor cells
loop mediated isothermal amplification
endothelial cells
machine learning
circulating tumor
real time pcr
deep learning
induced pluripotent stem cells
high fat diet induced
metabolic syndrome
patient reported outcomes
skeletal muscle
sensitive detection
wild type