Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction.

Mingxiang WangJin LiShunni DongXiaobo CaiAili SimaitiXin YangXinqiang ZhuJianhong LuoLin-Hua JiangBinyang DuPeilin YuWei Yang

Published in: Particle and fibre toxicology (2020)

The ROS/PARP/TRPM2 signaling is critical in SiNPs-induced pulmonary inflammation, providing novel mechanistic insights into NPs-induced lung injury. Our study identifies TRPM2 channel as a new target for the development of preventive and therapeutic strategies to mitigate nanomaterials-induced lung inflammation.

Keyphrases

oxidative stress
diabetic rats
dna damage
high glucose
cell death
drug induced
dna repair
pulmonary hypertension
type diabetes
gene expression
dna methylation
insulin resistance
high fat diet induced
living cells