Clinicopathological and genomic features of superficial esophageal squamous cell carcinomas in nondrinker, nonsmoker females.

Motomitsu FukuharaYuji UrabeHikaru NakaharaAkira IshikawaKazuki IshibashiHirona KonishiJunichi MizunoHidenori TanakaAkiyoshi TsuboiKen YamashitaYuichi HiyamaHidehiko TakigawaTakahiro KotachiRyo YugeC Nelson HayesShiro Oka

Published in: Cancer medicine (2024)

Older nondrinker, nonsmoker females with RE and fewer multiple LVLs may develop longitudinal 0-IIa ESCC with keratinization of the posterior wall of the mid-thoracic esophagus. ESCCs in nondrinker, nonsmoker females had fewer KMT2D alterations and more CDKN2A alterations, which may be a biomarker for treatment.

Keyphrases

squamous cell
spinal cord
physical activity
high grade
middle aged
copy number
community dwelling
gene expression
combination therapy
dna methylation
replacement therapy