Unexpected triaxial preferences in some all- syn 1,3,5-trifluorocyclohexanes.
Cihang YuBruno A PiscelliNawaf Al MaharikDavid Bradford CordesAlexandra M Z SlawinRodrigo A CormanichDavid O'HaganPublished in: Chemical communications (Cambridge, England) (2022)
Theory and solution NMR indicate that all- syn 1,3,5-trifluorocyclohexane 5 adopts the expected tri-equatorial conformation, however in the solid state the more polar triaxial conformation is observed. This and the favoured conformations of substituted (Me, OMe, NH(CO)Me, NHBoc) derivatives of 5 are investigated to explore triaxial C-F preferences.