Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis.
Ang LiAi-Jun ChenJing XuZhu-Yuan WenGen-Long BaiZi-Yue WangYu-Xin JiangPing WangPublished in: Molecular biology reports (2024)
Rapamycin can alleviate skin photodamage from Hspb2 knockout to some extent. It may be a potential therapeutic drug for skin photodamage. In this study, we investigated the role of rapamycin and Hspb2 in UVB-induced photodamage in mice. Histological results showed that knockout of the hspb2 exacerbated the skin damage, as evidenced by thickening of the epidermis, breakage and disruption of collagen fibers and reduction in their number, which is reversed by rapamycin treatment. In addition, hspb2 knockout promoted UVB-induced apoptosis and reduced autophagy levels. Rapamycin was also found to inhibit collagen degradation induced by hspb2 knockdown through activation of the TGF-β/Smad signaling pathway. We conclude that rapamycin and Hspb2 exert a synergistic protective effect in skin photodamage.
Keyphrases
- heat shock protein
- heat shock
- signaling pathway
- induced apoptosis
- endoplasmic reticulum stress
- wound healing
- oxidative stress
- soft tissue
- diabetic rats
- cell death
- epithelial mesenchymal transition
- high glucose
- pi k akt
- transforming growth factor
- heat stress
- drug induced
- type diabetes
- emergency department
- metabolic syndrome
- cell cycle arrest
- drug delivery
- stress induced
- cancer therapy
- high resolution
- insulin resistance
- adverse drug
- high fat diet induced