Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy.
Jinkyung LeeSuhyun KimYoon Hwan KimUiyeol ParkJunghee LeeAnn C McKeeKyoung Heon KimHoon RyuJeongae LeePublished in: Biomedicines (2022)
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is frequently found in athletes and those who have experienced repetitive head traumas. CTE is associated with a variety of neuropathologies, which cause cognitive and behavioral impairments in CTE patients. However, currently, CTE can only be diagnosed after death via brain autopsy, and it is challenging to distinguish it from other neurodegenerative diseases with similar clinical features. To better understand this multifaceted disease and identify metabolic differences in the postmortem brain tissues of CTE patients and control subjects, we performed ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS)-based non-targeted metabolomics. Through multivariate and pathway analysis, we found that the brains of CTE patients had significant changes in the metabolites involved in astrocyte activation, phenylalanine, and tyrosine metabolism. The unique metabolic characteristics of CTE identified in this study were associated with cognitive dysfunction, amyloid-beta deposition, and neuroinflammation. Altogether, this study provided new insights into the pathogenesis of CTE and suggested appealing targets for both diagnosis and treatment for the disease.
Keyphrases
- mass spectrometry
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- spinal cord injury
- peritoneal dialysis
- prognostic factors
- ms ms
- traumatic brain injury
- cancer therapy
- patient reported outcomes
- resting state
- white matter
- single cell
- brain injury
- drug delivery
- patient reported
- functional connectivity
- cognitive impairment
- ultra high performance liquid chromatography
- high performance liquid chromatography