Decarboxylative Csp3-N Bond Formation by Electrochemical Oxidation of Amino Acids.
Xiaoqing ShaoYue ZhengLifang TianInmaculada Martín-TorresAntonio M EchavarrenYahui WangPublished in: Organic letters (2019)
Decarboxylative Csp3-N coupling reactions have been developed through electrochemical oxidation of amino acids. The reaction proceeds via anodic oxidative decarboxylation of carboxylic acids to form stabilized carbocations, which are trapped by azoles or amides to construct C-N bonds. This method avoids the preactivation of carboxylic acids and the use of expensive transition-metals and external chemical oxidants.
Keyphrases
- electron transfer
- amino acid
- visible light
- gold nanoparticles
- ionic liquid
- molecularly imprinted
- hydrogen peroxide
- human health
- label free
- health risk assessment
- health risk
- room temperature
- risk assessment
- high resolution
- heavy metals
- transition metal
- simultaneous determination
- solid phase extraction
- tandem mass spectrometry