Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease.

Irina BelayaMariia IvanovaAnnika SorvariMarina IlicicSanna LoppiHennariikka KoivistoAlessandra VarricchioHeikki TikkanenFrederick R WalkerMustafa AtalayTarja MalmAlexandra GrubmanHeikki TanilaKatja M Kanninen

Published in: Journal of neuroinflammation (2020)

Voluntary physical exercise modulates the reactive astrocyte state, which could be linked via astrocytic BDNF and PSD-95 to improved cognition in 5xFAD hippocampi. The molecular pathways involved in this modulation could potentially be targeted for benefit against AD.

Keyphrases

high intensity
cognitive decline
mild cognitive impairment
cancer therapy
physical activity
white matter
resistance training
stress induced
multiple sclerosis
drug delivery
body composition