Associations between near end-of-life flortaucipir PET and postmortem CTE-related tau neuropathology in six former American football players.
Michael L AloscoYi SuThor D SteinHillary ProtasJonathan D CherryCharles H AdlerLaura J BalcerCharles BernickSurya Vamsi PulukuriBobak AbdolmohammadiMichael J ColemanJoseph N PalmisanoYorghos TripodisJesse MezGil D RabinoviciKenneth L MarekThomas G BeachKeith A JohnsonBertrand Russell HuberInga KoerteAlexander P LinSylvain BouixJeffrey L CummingsMartha E ShentonEric M ReimanAnn C McKeeRobert A Sternnull nullPublished in: European journal of nuclear medicine and molecular imaging (2022)
Flortaucipir-PET could be useful for detecting high stage CTE neuropathology, but specificity to CTE p-tau is uncertain. Off-target flortaucipir binding in the hippocampus and thalamus complicates interpretation of these associations. In vivo biomarkers that can detect the specific p-tau of CTE across the disease continuum are needed.