Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy.
Cătălina Natalia Cheaburu YilmazDaniela PamfilCornelia VasileNela BibireRaoul-Vasile LupuşoruCarmen-Lăcrămioara ZamfirCătălina Elena LupușoruPublished in: Polymers (2017)
Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical⁻chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by "in vivo" tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2⁻7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease.
Keyphrases
- hyaluronic acid
- electron microscopy
- high dose
- high resolution
- oxidative stress
- physical activity
- mental health
- drug delivery
- liver failure
- alcohol consumption
- low dose
- single molecule
- stem cells
- respiratory failure
- intensive care unit
- mass spectrometry
- oxide nanoparticles
- cancer therapy
- cell therapy
- ionic liquid
- aortic dissection
- replacement therapy
- tissue engineering