The impact of preventive treatment for multidrug- and rifampin-resistant tuberculosis exceeds trial-based estimates.

Parastu KasaieJeff PenningtonAmita GuptaDavid W DowdyEmily A Kendall

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

If forthcoming trial results demonstrate efficacy, the long-term population impact of TPT for MDR/RR-TB - including the large effect of increased active TB detection among MDR/RR-TB contacts - could be much greater than suggested by trial outcomes alone.

Keyphrases

mycobacterium tuberculosis
phase iii
study protocol
phase ii
clinical trial
multidrug resistant
open label
drug resistant
emergency department
pulmonary tuberculosis
metabolic syndrome
quantum dots
label free
adverse drug