A flexible and physically transient electrochemical sensor for real-time wireless nitric oxide monitoring.
Rongfeng LiHui QiYuan MaYuping DengShengnan LiuYongsheng JieJinzhu JingJinlong HeXu ZhangLaura WheatleyCongxi HuangXing ShengMilin ZhangLan YinPublished in: Nature communications (2020)
Real-time sensing of nitric oxide (NO) in physiological environments is critically important in monitoring neurotransmission, inflammatory responses, cardiovascular systems, etc. Conventional approaches for NO detection relying on indirect colorimetric measurement or built with rigid and permanent materials cannot provide continuous monitoring and/or require additional surgical retrieval of the implants, which comes with increased risks and hospital cost. Herein, we report a flexible, biologically degradable and wirelessly operated electrochemical sensor for real-time NO detection with a low detection limit (3.97 nmol), a wide sensing range (0.01-100 μM), and desirable anti-interference characteristics. The device successfully captures NO evolution in cultured cells and organs, with results comparable to those obtained from the standard Griess assay. Incorporated with a wireless circuit, the sensor platform achieves continuous sensing of NO levels in living mammals for several days. The work may provide essential diagnostic and therapeutic information for health assessment, treatment optimization and postsurgical monitoring.
Keyphrases
- nitric oxide
- label free
- gold nanoparticles
- loop mediated isothermal amplification
- hydrogen peroxide
- real time pcr
- high throughput
- public health
- health information
- risk assessment
- cell cycle arrest
- human health
- social media
- cell proliferation
- blood brain barrier
- living cells
- low cost
- cerebral ischemia
- pi k akt
- endoplasmic reticulum stress
- quantum dots
- solid phase extraction