Single-cell sequencing on CD8 + TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
Hiroyasu KomuroShuichi ShinoharaYasunori FukushimaAyako Demachi-OkamuraDaisuke MuraokaKatsuhiro MasagoTakuya MatsuiYusuke SugitaYusuke TakahashiReina NishidaChieko TakashimaTakashi OhkiYoshiki ShigematsuFumiaki WatanabeKatsutoshi AdachiTakashi FukuyamaHiroshi HamanaHiroyuki KishiDaiki MiuraYuki TanakaKousuke OnoueKazuhide OnoguchiYoshiko YamashitaRichard StratfordTrevor ClancyRui YamaguchiHiroaki KurodaKiyoshi DoiHisashi IwataHirokazu MatsushitaPublished in: Journal for immunotherapy of cancer (2023)
TILs may facilitate the identification of tumor antigens and clarify the nature of the antigen-specific T cells to specify the promising immunotherapeutic targets in patients with NSCLC.