Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study.
Christopher T RentschJoshua A BeckmanLaurie TomlinsonWalid F GelladCharles AlcornFarah Kidwai-KhanMelissa SkandersonEvan BrittainJoseph T KingYuk-Lam HoSvetlana EdenSuman KunduMichael F LannRobert A GreevyP Michael HoPaul A HeidenreichDaniel A JacobsonIan J DouglasJanet P TateStephen J W EvansDavid AtkinsAmy C JusticeMatthew S FreibergPublished in: BMJ (Clinical research ed.) (2021)
Early initiation of prophylactic anticoagulation compared with no anticoagulation among patients admitted to hospital with covid-19 was associated with a decreased risk of 30 day mortality and no increased risk of serious bleeding events. These findings provide strong real world evidence to support guidelines recommending the use of prophylactic anticoagulation as initial treatment for patients with covid-19 on hospital admission.