Login / Signup

AKT1 interacts with DHX9 to Mitigate R Loop-Induced Replication Stress in Ovarian Cancer.

Tzu-Ting HuangChih-Yuan ChiangJayakumar R NairKelli M WilsonKen ChengJung-Min Lee
Published in: Cancer research (2024)
Inhibition of the AKT and ATR pathways cooperatively induces R loop-associated replication stress in high-grade serous ovarian cancer, providing rationale to support the clinical development of AKT and ATR inhibitor combinations. See related commentary by Ramanarayanan and Oberdoerffer, p. 793.
Keyphrases
  • high grade
  • signaling pathway
  • cell proliferation
  • low grade
  • transcription factor
  • dna damage response
  • high glucose
  • clinical trial
  • drug induced
  • diabetic rats
  • endothelial cells
  • binding protein
  • heat stress