Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells.

Ziwen CaiMiaomiao ZhuLi XuYue WangYin XuWai Yen YimHong CaoRuikang GuoXiang QiuXimiao HeJiawei ShiWeiHua Qiao Nianguo Dong

Published in: Circulation (2024)

In summary, this is the first study to report an efficient strategy to generate functional hiPSC-derived valve endothelial-like cells and hiPSC-derived valve interstitial-like cells from hiPSCs, as well as to elucidate the differentiation trajectory and transcriptional dynamics of hiPSCs differentiated into heart valve cells.

Keyphrases

aortic valve
induced pluripotent stem cells
mitral valve
induced apoptosis
aortic stenosis
endothelial cells
cell cycle arrest
heart failure
transcatheter aortic valve replacement
ejection fraction
endoplasmic reticulum stress
signaling pathway
oxidative stress