Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst.
Nádia Marielly Gomes BatistaAntonia Taiane Lopes de MoraesKarolyny Martins BalbinotOsvaldo Rodrigues de Souza NetoJuliana Melo da Silva BrandãoMaria Sueli da Silva KataokaSérgio de Melo Alves JúniorJoão de Jesus Viana PinheiroPublished in: BMC oral health (2021)
Our results suggest that the studied proteins may participate in the pathogenesis of PG and RC, through the interaction of these proteins, in the remodeling of the ECM (versican) by ADAMTS-1, producing bioactive fragments, which could activate EGFR, contributing to the formation, growth and maintenance of injuries.