Epidemiology of paediatric gastrointestinal colonisation by extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in north-west Cambodia.

Jon van AartsenC E MooreC M ParryP TurnerN PhotS MaoK SuyT DaviesA GiessA E SheppardT E A PetoN P J DayD W CrookA S WalkerN Stoesser

Published in: BMC microbiology (2019)

Gastrointestinal ESC-R-EC/KP colonisation is widespread in Cambodian children/adolescents; hospital admission and intestinal parasites are independent risk factors. The genetic contexts of blaCTX-M are highly mosaic, consistent with rapid horizontal exchange. Chromosomal integration of blaCTX-M may result in stable propagation in these community-associated pathogens.

Keyphrases

klebsiella pneumoniae
escherichia coli
risk factors
multidrug resistant
gram negative
young adults
emergency department
healthcare
copy number
mental health
intensive care unit
genome wide
tertiary care
genetic diversity
adverse drug
biofilm formation
acute care
plasmodium falciparum
staphylococcus aureus