Monocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis.

Shixian ChenChunqing GuoRan WangZhitao FengZheng LiuLisheng WuDi ZhaoSongyuan ZhengFeilong ChenDingding ZhangJuan XuJunqing ZhuXiaoguang ChenZhanguo LiChristopher M WiseJuan LiXiang-Yang Wang

Published in: Rheumatology (Oxford, England) (2021)

Our findings highlight the functional plasticity of MDSCs and identify a novel pro-osteoclastogenic pathway governed by interplay between myeloid cells and T lymphocytes in autoimmune RA.

Keyphrases

rheumatoid arthritis
induced apoptosis
cell cycle arrest
disease activity
multiple sclerosis
endoplasmic reticulum stress
bone marrow
oxidative stress
acute myeloid leukemia
cell death
ankylosing spondylitis
interstitial lung disease