Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance.
Álvaro González-DomínguezThalía BelmonteJesús Domínguez-RiscartPablo Ruiz-OcañaInés Muela-ZarzuelaAna Saez-BenitoRaúl Montañez-MartínezRosa M MateosAlfonso María Lechuga-SanchoPublished in: Journal of translational medicine (2023)
It is insulin response to an OGTT that identifies children with obesity suffering oxidative stress and inflammasome activation more specifically. Uric acid could be mediating this pathological inflammatory response by activating NLRP3 in peripheral blood mononuclear cells.
Keyphrases
- insulin resistance
- metabolic syndrome
- uric acid
- oxidative stress
- type diabetes
- inflammatory response
- high fat diet induced
- young adults
- weight loss
- high fat diet
- adipose tissue
- skeletal muscle
- glycemic control
- dna damage
- polycystic ovary syndrome
- weight gain
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- signaling pathway
- body mass index
- lipopolysaccharide induced
- physical activity
- immune response
- endoplasmic reticulum stress