Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci.
Alex Ranieri Jerônimo LimaHerbert Guimarães de Sousa SilvaSaloe PoubelJuliana Nunes RosónLoyze Paola Oliveira de LimaHéllida Marina Costa-SilvaCamila Silva GonçalvesPedro A F GalanteFabiola HoletzMaria Cristina Machado MottaAriel M SilberM Carolina EliasJulia Pinheiro Chagas da CunhaPublished in: Epigenetics & chromatin (2022)
Taken together, our results indicate that chromatin changes reflect the unusual gene expression regulation of trypanosomes and the differences among parasite developmental stages, even in the context of a lack of canonical transcriptional control of protein-coding genes.