Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop.

Yan WangXiang WangKai WangJi QiYu ZhangXu WangLong ZhangYi ZhouLinbo GuRutong YuXiu-Ping Zhou

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our study revealed that chronic stress accelerates GBM progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop. DRD2 together with β-catenin may serve as a potential predictive biomarker for worse prognosis as well as therapeutic target of GBM patients with depression.

Keyphrases

cell proliferation
signaling pathway
pi k akt
epithelial mesenchymal transition
transcription factor
uric acid
depressive symptoms
stress induced
climate change
risk assessment
physical activity
heat stress
drug induced