A second administration of glucarpidase in a different cycle of high-dose methotrexate: Is it safe and effective in adults?
Amalia Domingo-GonzálezSantiago OsorioElena LandeteSilvia MonsalvoJose L Díez-MartínPublished in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)
The effectiveness and safety of the use of glucarpidase in different episodes of nephrotoxicity remain an unknown area, and the rate and consequences of antiglucarpidase antibody formation remain poorly understood. This case report is, to our knowledge, the first case of a second administration of glucarpidase in a different cycle of high-dose methotrexate in an adult patient.