An integrative analysis identifying transcriptional features and key genes involved in COVID-19.
Guoping LiJunyi WangXiang HeLei ZhangQin RanAnying XiongDehong WuLingjuan HuQi SongDong ZhuPublished in: Epigenomics (2020)
Aim: To elucidate the transcriptional characteristics of COVID-19. Materials & methods: We utilized an integrative approach to comprehensively analyze the transcriptional features of both COVID-19 patients and SARS-CoV-2 infected cells. Results: Widespread infiltration of immune cells was observed. We identified 233 genes that were codifferentially expressed in both bronchoalveolar lavage fluid and lung samples of COVID-19 patients. Functional analysis suggested upregulated genes were related to immune response such as neutrophil activation and antivirus response, while downregulated genes were associated with cell adhesion. Finally, we identified LCN2, STAT1 and UBE2L6 as core genes during SARS-CoV-2 infection. Conclusion: The identification of core genes involved in COVID-19 can provide us with more insights into the molecular features of COVID-19.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- bioinformatics analysis
- coronavirus disease
- genome wide
- immune response
- gene expression
- genome wide identification
- cell adhesion
- transcription factor
- induced apoptosis
- heat shock
- oxidative stress
- cell proliferation
- toll like receptor
- dendritic cells
- endoplasmic reticulum stress
- inflammatory response
- data analysis