Reduction of mitochondria and up regulation of pyruvate dehydrogenase kinase 4 of skeletal muscle in patients with chronic kidney disease.

Chenqi XuAyijiaken KasimumaliXiangjiang GuoRenhua LuKewei XieMingli ZhuYingying QianXiaohuan ChenHuihua PangQin WangZhuping FanHuili DaiShan MouZhaohui NiLeyi Gu

Published in: Nephrology (Carlton, Vic.) (2019)

Decreased mitochondria and PDH deficiency caused by up regulation of PDK 4 contribute to muscle dysfunction, and could be responsible for muscle weakness in CKD patients.

Keyphrases

skeletal muscle
end stage renal disease
chronic kidney disease
cell death
newly diagnosed
ejection fraction
insulin resistance
oxidative stress
prognostic factors
reactive oxygen species
type diabetes
endoplasmic reticulum
metabolic syndrome
adipose tissue
myasthenia gravis