Pathological manifestation of the induced pluripotent stem cell-derived cortical neurons from an early-onset Alzheimer's disease patient carrying a presenilin-1 mutation (S170F).

Ling LiHee Jin KimJee Hoon RohMinchul KimWonyoung KohYounghoon KimHyohoon HeoJaehoon ChungMahito NakanishiTaeyoung YoonChang Pyo HongSang Won SeoDuk L NaJihwan Song

Published in: Cell proliferation (2020)

Taken together, we have established and characterized the pathological features of an AD patient carrying PS1-S170F mutation using iPSC technology, which will be the first case on this mutation and this iPSC line will serve as a useful resource for studying AD pathogenesis and drug screening in the future.

Keyphrases

early onset
late onset
case report
drug induced
cognitive decline
emergency department
diabetic rats
current status
adverse drug
endothelial cells
mild cognitive impairment