Adaptation of a population pharmacokinetic model to inform tacrolimus therapy in heart transplant recipients.

Ranita KirubakaranDavid W UsterStefanie Hennig Jane Ellen Carland Richard Osborne Day Sebastian Georg Wicha Sophie Lena Stocker

Published in: British journal of clinical pharmacology (2022)

A population pharmacokinetic model that adequately describes tacrolimus pharmacokinetics in heart transplant recipients, considering the tacrolimus-azole antifungal interaction was developed. Prospective evaluation is required to assess its clinical utility to improve patient outcomes.

Keyphrases

candida albicans
heart failure
stem cells
mesenchymal stem cells
bone marrow