Histomorphometric and immunohistochemical changes in interstitial cells and ovarian follicles of rats with polycystic ovaries treated with clomiphene citrate.

Leonardo Augusto LombardiLeandro Sabará MattosRicardo Santos SimõesRinaldo Florencio-SilvaManuel de Jesus SimõesPaulo Celso FrancoAdriana Aparecida Ferraz CarbonellGisela Rodrigues da Silva SassoEdmund Chada BaracatJosé Maria Soares Júnior

Published in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2020)

The ovaries of rats treated with clomiphene citrate showed a decrease in the number of cysts, an increase in the number of ovarian follicles, the presence of corpus luteum along with a decrease in the nuclear volume in the area occupied by interstitial cells.

Keyphrases

induced apoptosis
cell cycle arrest
polycystic ovary syndrome
oxidative stress
signaling pathway
skeletal muscle
pi k akt