Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory.

R G ValenciaE MihailovskaLilli WinterK BauerI FischerG WalkoJ JorgacevskiM PotokarRobert Zorec Gerhard Wiche

Published in: Neuropathology and applied neurobiology (2020)

Revealing a regulatory role of plectin scaffolds in microtubule-dependent nerve cell functions, our results have potential implications for cytoskeleton-related neuropathies.

Keyphrases

chronic pain
single cell
pain management
spinal cord
neuropathic pain
cell therapy
oxidative stress
working memory
transcription factor
cerebrospinal fluid
tissue engineering
stem cells
peripheral nerve
spinal cord injury
climate change