Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory.
R G ValenciaE MihailovskaLilli WinterK BauerI FischerG WalkoJ JorgacevskiM PotokarRobert ZorecGerhard WichePublished in: Neuropathology and applied neurobiology (2020)
Revealing a regulatory role of plectin scaffolds in microtubule-dependent nerve cell functions, our results have potential implications for cytoskeleton-related neuropathies.