GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
Wenjun PengYuanyuan WuGe ZhangWensi ZhuMeijia ChangAiniwaer RouziWeipeng JiangLin TongQin WangJie LiuYuanlin SongHuayin LiKa LiJian ZhouPublished in: International journal of chronic obstructive pulmonary disease (2021)
To conclude, GLIPR1 played a pivotal role in COPD pathogenesis and protected against CS-induced inflammatory response and airway damage, including cell pyroptosis, through the PLAU/EGFR signaling. Thus, GLIPR1 may play a potential role in COPD treatment.
Keyphrases
- inflammatory response
- small cell lung cancer
- chronic obstructive pulmonary disease
- high glucose
- diabetic rats
- epidermal growth factor receptor
- tyrosine kinase
- lung function
- oxidative stress
- drug induced
- single cell
- lipopolysaccharide induced
- cell therapy
- endothelial cells
- stem cells
- immune response
- cystic fibrosis
- nlrp inflammasome
- bone marrow
- toll like receptor
- lps induced
- replacement therapy