Left anterior descending artery disease in a 27-year-old with multiple endocrine neoplasia, type 2A: A case report.
Mohammed Omar Al SalihiMurali K IyyaniSarina KoilpillaiGerson QuinteroJorge ParelladaStephen J CarlanPublished in: SAGE open medical case reports (2023)
Multiple endocrine neoplasia 2A is an autosomal dominant disease characterized by medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism. Coronary artery disease is associated with the disorder, but the mechanism is unclear. A 27-year-old female presented with chest pain and palpitations. A left heart catheterization was performed and showed 80% stenosis of the left anterior descending artery. Imaging and workup also revealed primary hyperparathyroidism associated with a parathyroid adenoma and elevated serum and urine metanephrines and norepinephrines. A computed tomography of the abdomen revealed a large heterogeneous right adrenal mass measuring 7.9 cm × 6.8 cm × 8 cm consistent with a pheochromocytoma. The patient subsequently underwent adrenal mass resection and a complete thyroidectomy and parathyroidectomy. Early recognition and treatment of multiple endocrine neoplasia 2A can possibly reduce the risk of lethal heart disease in addition to the other associated endocrine disturbances.
Keyphrases
- high grade
- coronary artery disease
- computed tomography
- heart failure
- high resolution
- magnetic resonance imaging
- percutaneous coronary intervention
- case report
- cardiovascular disease
- squamous cell carcinoma
- type diabetes
- cardiovascular events
- acute coronary syndrome
- ultrasound guided
- coronary artery bypass grafting
- combination therapy
- mass spectrometry
- lymph node metastasis
- pet ct
- fluorescence imaging
- transcatheter aortic valve replacement
- replacement therapy
- dual energy
- aortic valve