Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020.
Sara KildgaardLívia S de MedeirosEmma PhillipsCharlotte H GotfredsenJens C FrisvadKristian F NielsenLucas M AbreuThomas Ostenfeld LarsenPublished in: Journal of natural products (2018)
Cyclopiamines C (1) and D (2) were isolated from the extract of Penicillium sp. CML 3020, a fungus sourced from an Atlantic Forest soil sample. Their structures and relative configuration were determined by 1D and 2D NMR, HRMS, and UV/vis data analysis. Cyclopiamines C and D belong to a small subset of rare spiroindolinone compounds containing an alkyl nitro group and a 4,5-dihydro-1 H-pyrrolo[3,2,1- ij]quinoline-2,6-dione ring system. NMR and MS/HRMS data confirmed the presence of an epoxide unit (C-17-O-C-18) and a hydroxy group at C-5, not observed for their known congeners. Cytotoxic and antimicrobial activities were evaluated.
Keyphrases
- data analysis
- high resolution
- magnetic resonance
- solid state
- high resolution mass spectrometry
- mass spectrometry
- climate change
- staphylococcus aureus
- multiple sclerosis
- chronic myeloid leukemia
- oxidative stress
- liquid chromatography
- molecular docking
- ionic liquid
- electronic health record
- anti inflammatory
- simultaneous determination
- solid phase extraction
- cell wall