Enhancing CD19 Chimeric Antigen Receptor T Cells Through Memory-Enriched T Cells.
Ettaib El MarabtiOmar Abdel-WahabPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Chimeric antigen receptor T (CAR-T) cells directed against CD19 have transformed the therapy of relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). A recent study reports promising activity and safety of CD19 CAR-T cells generated from naïve, stem, and central memory T cells in adults with R/R B-ALL. See related article by Aldoss et al., p. 742.
Keyphrases
- acute lymphoblastic leukemia
- induced apoptosis
- working memory
- nk cells
- acute myeloid leukemia
- allogeneic hematopoietic stem cell transplantation
- multiple myeloma
- stem cells
- emergency department
- cell cycle arrest
- hodgkin lymphoma
- signaling pathway
- endoplasmic reticulum stress
- bone marrow
- adverse drug
- smoking cessation