Systemic high-dose intravenous methotrexate in patients with central nervous system metastatic breast cancer.

F BazanE DobiB RoyerE CurtitL MansiN MenneveauM J PaillardG MeynardC VillanuevaX PivotLoïc Chaigneau

Published in: BMC cancer (2019)

High-dose MTX demonstrated a moderate activity at 3 g/m2. Nonetheless, the favorable toxicity profile should suggest the possibility to increase the dosage and further study are planned.

Keyphrases

high dose
metastatic breast cancer
stem cell transplantation
low dose
oxidative stress
high intensity
cerebrospinal fluid