Identification of Immune-Related Genes and Small-Molecule Drugs in Interstitial Cystitis/Bladder Pain Syndrome Based on the Integrative Machine Learning Algorithms and Molecular Docking.
Deyong YangXinqing ZhuAbdullah Y Al-DanakhQiwei ChenDeyong YangPublished in: Journal of immunology research (2022)
We found and validated 5 immune-related IC/BPS genes (RASGRP1, PPBP, RBP4, CR2, and PROS2) and 2 IC/BPS immune subtypes. In addition, bumetanide was discovered to be a potential drug for treating IC/BPS, which may provide new insight into the diagnosis and immune therapy of IC/BPS patients.
Keyphrases
- machine learning
- molecular docking
- small molecule
- ejection fraction
- end stage renal disease
- newly diagnosed
- deep learning
- genome wide
- gene expression
- emergency department
- prognostic factors
- mesenchymal stem cells
- stem cells
- dna methylation
- patient reported outcomes
- drug induced
- transcription factor
- human health
- genome wide identification
- replacement therapy