Higher oxygen saturation with hydroxyurea in paediatric sickle cell disease.

Lisa van GeyzelMichele AriglianiBaba InusaBethany SinghWanda KozlowskaSubarna ChakravortyCara J BossleyGary RuizDavid ReesAtul Gupta

Published in: Archives of disease in childhood (2019)

Children with SCD had higher oxygen saturation overnight and on daytime spot checks after starting HU. These data suggest HU may be helpful for treating persistent hypoxaemia in children with SCD pending more evidence from a randomised clinical trial.

Keyphrases

sickle cell disease
clinical trial
young adults
open label
double blind
study protocol
emergency department
obstructive sleep apnea
electronic health record
big data
phase ii
machine learning
sleep quality
physical activity
depressive symptoms
phase iii
artificial intelligence
data analysis