Candidate Tracers for Imaging Colony-Stimulating Factor 1 Receptor in Neuroinflammation with Positron Emission Tomography: Issues and Progress.
Stefano AltomonteVictor W PikePublished in: ACS pharmacology & translational science (2023)
The tyrosine kinase, colony-stimulating factor 1 receptor (CSF1R), has attracted attention as a potential biomarker of neuroinflammation for imaging studies with positron emission tomography (PET), especially because of its location on microglia and its role in microglia proliferation. The development of an effective radiotracer for specifically imaging and quantifying brain CSF1R is highly challenging. Here we review the progress that has been made on PET tracer development and discuss issues that have arisen and which remain to be addressed and resolved.
Keyphrases
- positron emission tomography
- computed tomography
- pet imaging
- tyrosine kinase
- high resolution
- pet ct
- inflammatory response
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- epidermal growth factor receptor
- neuropathic pain
- signaling pathway
- mass spectrometry
- cerebral ischemia
- multiple sclerosis
- resting state
- fluorescence imaging
- spinal cord injury
- functional connectivity
- binding protein
- case control