Neurofibromatosis-associated malignant peripheral nerve sheath tumors in children have a worse prognosis: A nationwide cohort study.
Enrico MartinJ Henk CoertUta E FluckeWillem-Bart M SlooffMichiel A J van de SandeMax M Van NoeselDirk J GrünhagenMarc H W A WijnenCornelis VerhoefPublished in: Pediatric blood & cancer (2019)
Pediatric MPNSTs have presentations similar to adult MPNSTs. In children, NF1 patients present with larger tumors, but are treated similarly to non-NF1 MPNSTs. In localized pediatric MPNST, NF1 is associated with worse survival. Promisingly, survival has increased for pediatric MPNSTs after 2005.
Keyphrases
- ejection fraction
- signaling pathway
- peripheral nerve
- lps induced
- young adults
- pi k akt
- oxidative stress
- nuclear factor
- childhood cancer
- inflammatory response
- free survival
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- toll like receptor
- cell proliferation
- peritoneal dialysis
- prognostic factors
- patient reported outcomes