Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke.
Yan LiZi-Yu ZhuBing-Wei LuTing-Ting HuangYue-Man ZhangNa-Ying ZhouWei XuanZeng-Ai ChenDa-Xiang WenWei-Feng YuPei-Ying LiPublished in: CNS neuroscience & therapeutics (2019)
RSG treatment protects against BBB damage and ameliorates HT in delayed tPA-treated stroke mice by activating PPAR-γ and favoring microglial polarization toward anti-inflammatory phenotype.
Keyphrases
- anti inflammatory
- mouse model
- blood brain barrier
- oxidative stress
- high glucose
- cerebral ischemia
- diabetic rats
- signaling pathway
- inflammatory response
- white matter
- insulin resistance
- resting state
- high fat diet induced
- drug induced
- neuropathic pain
- endothelial cells
- adipose tissue
- spinal cord injury
- wild type
- skeletal muscle
- newly diagnosed
- stress induced