Phenol/croton oil is a unique chemical formulation promoting deep skin resurfacing and cellular renovation. Even though it has been used for decades in plastic surgery, the clinicopathological features, as well as the risks related to phenol/croton oil clinical application have not been thoroughly studied. The aim of the present study was to assess the effectiveness of the phenol/croton oil peel, the pathological characteristics from 1 patient at least and the emerging potential risks. A total of 64 patients were treated with phenol/croton oil peel between 2014 and 2023; in total, 21 of them underwent resurfacing at their oral area (upper/lower lips), 15 underwent resurfacing at their lower eyelid wrinkles, 22 patients underwent full face resurfacing, 2 patients were treated for their acne scars and additionally 4 patients were treated for multiple body seborrheic keratosis. The wrinkles, as well as the acne scars were markedly improved in all patients, the seborrheic keratosis was eliminated, while adverse events and undesired clinical manifestations related to peel intervention were mild and reversible for all patients. The application of phenol/croton oil constitutes an immensely powerful tool for deep chemical peeling and facial skin rejuvenation; nevertheless, it should be used cautiously due to its potential complications.